Autoimmune diseases (like arthritis), is a case where your immune system targets your body’s own tissue and destroys it with inflammation, and is understandably extremely interesting to medical scientists.
To put it simply, why would such an otherwise sophisticated and well-constructed body do such a stupid thing?
Scientists from the Technical University of Munich have now explained the process whereby this occurs in detail in a new study in the journal Cell Report.
And this may lead to a clearer path towards a cure for arthritis.
Your immune system must attack and remove everything it considers to be an abnormal biological material. To do this, it uses T-cells to attack invaders, and also to remove cells that have been damaged and that are identified as abnormal.
These T-cells are incredibly strong and often use inflammation to kill invaders.
The only problem? If the cells in your joints, for example, have been slightly damaged by a relatively normal biological process, such as oxidation or by harmless bacteria, these T-cells will destroy your joints until nothing remains of it.
This is where regulatory T-cells, or Tregs, step in. The job of Tregs is to inhibit unnecessarily strong responses by these T-cells and to block unnecessarily strong inflammation.
In other words, when your T cells begin to destroy your joints because your immune system incorrectly labels them as harmful, these Tregs stop the immune overreaction, curb the inflammation, send the T-cells away, thereby saving your joints.
If you have a condition like arthritis, however, then these Tregs are clearly not doing their job, and this is the puzzle that scientists are still trying to solve.
For some reason, particularly in the case of severely inflamed tissue, Tregs lose their identity and stop operating as the brake system that the immune system often needs, particularly in the misinterpreted cases. As such, the authors of the new study used mice to investigate why this happens.
When they observed severely inflamed tissue in mice, they noticed that a protein called Blimp1 was sometimes present and sometimes absent.
When it was present and active, the Tregs worked. When it was absent, the Tregs lost their identity and remained inactive.
When they deliberately removed Blimp1 from the mice’s inflamed tissue, the mice developed something akin to an autoimmune disease.
Not only did the Tregs lose their abilities to inhibit the immune response, but they also seemed to develop properties that made them prone to inflammation promotion.
This is partly why many autoimmune diseases are genetic, as it is a genetic process that activates Blimp1.
This is groundbreaking research, as it is the first time that scientists have managed to get a glimpse of why the immune system is so dysfunctional in autoimmune diseases like arthritis.
Unfortunately, it will still be years before this discovery translates into any form of functional medication for arthritis. Till then, we will have to rely on diet and other lifestyle changes to tackle inflammation.
Treat Degenerative Arthritis – Stress And Arthritis – Strange Pain Connection
Around 30% of those who suffer from arthritis pain also report a high level of stress. This is almost three times the stress level of the general public.
A new study published in the journal Arthritis Research & Therapy reveals that people with arthritis can almost eliminate their pain and stress level at the same time.
The researchers recruited 241 people with joint pain, some of whom went on to develop rheumatoid arthritis and some of whom did not.
They measured the levels of psychological stress of these participants with the Mental Health Inventory and the Perceived Stress Scale at the beginning of the study and during follow-up visits.
They measured their systemic inflammation with a blood test for a pro-inflammatory chemical called C-reactive protein.
They also measured their joint inflammation using a magnetic resonance imaging (MRI) scan of their wrist, finger, and toe joints.
At the beginning of the study, 12% of people with joint pain suffered from high levels of psychological stress.
The moment arthritis was diagnosed, their stress levels increased until 31% of them experienced high stress.
So being diagnosed with such a serious disease increased stress and therefore joint pain.
Luckily, during the first year of treatment, stress levels dropped again, until only 8% of arthritis patients experienced extreme stress.
So, interestingly, by beginning to do something about their arthritis, the participants experienced lower stress levels than before they were diagnosed. This was true even if the traditional medical system had no cure.
Treat Degenerative Arthritis – The Weird Arthritis and Weight Loss Connection (different from what many might think)
One of the problems with arthritis is that because it limits people’s mobility, they move less and are therefore at increased risk of weight gain.
This often leads to severe disability.
So, the obvious solution is to lose weight. Right?
Not so fast, says a new study recently published in the journal Arthritis Care & Research. This study investigated the link between weight and disability due to arthritis.
At the beginning of the study, researchers expected to find that the most obese people were the most likely to suffer from arthritis that was related disability. They assumed that weight loss would be an effective treatment to halt the development of this disease.
They analyzed the medical data of 23,323 people with rheumatoid arthritis in the National Data Bank of Rheumatic Diseases, and of 1,697 arthritis sufferers in the Veterans Affairs RA registry.
Disability was measured according to the participant’s responses on the health assessment questionnaire.
When their details were first entered into these databases, it was found that those people who were obese would be substantially more likely than those who were overweight to suffer from arthritis-related disability.
In subsequent years, it was found that those who were obese were also much more likely than those who were overweight to develop such disabilities.
Where the study became surprising, however, was with the role of weight loss.
If obesity is the problem, then weight loss is the solution. Right?
Oddly enough, those who shed their weight did not benefit at all, and still experienced an increased risk of disability compared with people who were never obese or overweight to start off with.
The reason is that if you don’t reverse your arthritis (and the traditional medical system has no idea how), you can’t get your mobility back even if you lose weight.
Watch these 2 videos for more ideas to treat degenerative arthritis –
The study also shows that it is important to lose weight before you experience too much disability.
The problem is that most diets and workouts don’t work because they ignore the “third element of weight loss.” I’ll explain this third element here and show you how to use it to put your weight loss on autopilot…
This post is from the Arthritis Strategy Program. It was created by Shelly Manning, a former arthritis sufferer and a health consultant.
A Brief Background on the Author
Like you, Shelly Manning also suffered from arthritis, particularly osteoarthritis. This was due to her weight and desk job. Her condition eventually took a toll on her relationship with her (former) husband.
It was when she went to Hong Kong that she met Janerdquo, an old woman who owned the restaurant where she ate. Janerdquo supposedly offered her a bowl of a weird-smelling soup, which helped ease her joint pain. She ate there each day for 10 days until she was completely healed from arthritis.
Shelly Manning decided to research this natural remedy and to create a step-by-step treatment plan to others who are suffering from different types of arthritis, such as gout, rheumatoid arthritis, osteoarthritis, fibromyalgia, and psoriatic arthritis.
That’s why she created “The Arthritis Step By Step Strategy.” According to her claims, this unique strategy will get rid of joint pain and stiffness, repair your damaged joints, and treat the underlying cause of your arthritis.
Shelly teamed up with Christian Goodman, the owner of Blue Heron Health News, a publishing company that aims to help people to take responsibility for their own health by using natural health alternatives to reverse arthritis in fingers and knees naturally.
To find out more about this program, go to Treat Degenerative Arthritis Symptoms Naturally at Home
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